반응식
[C-:1]#[N:2].[K+].Br[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[C:12]([O:31][CH3:32])=[CH:13][CH:14]=[C:15]2[C:20]=1[O:19][C:18](=[O:21])[CH:17]=[C:16]2[NH:22][C:23]1[C:28]([Cl:29])=[CH:27][N:26]=[CH:25][C:24]=1[Cl:30]>>[Cl:30][C:24]1[CH:25]=[N:26][CH:27]=[C:28]([Cl:29])[C:23]=1[NH:22][C:16]1[C:15]2[C:20](=[C:11]([O:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][C:1]#[N:2])[C:12]([O:31][CH3:32])=[CH:13][CH:14]=2)[O:19][C:18](=[O:21])[CH:17]=1참가 물질
3
실험 절차
The title compound was prepared from potassium cyanide and 8-(5-bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one (Example 28) following the procedure outlined in Example 52. 1H NMR (400 MHz, DMSO-d6): δ 9.51 (s, 1H), 8.81 (s, 2H), 7.94 (d, 1H), 7.20 (d, 1H), 4.64 (s, 1H), 3.98 (t, 2H), 3.92 (s, 3H), 2.51 (t, 2H), 1.75-1.55 (m, 6H); MS (ESI): 447.9.
출처 및 근거
- ORD 기록
- ord-d8b5d156d5be4b658925fba2829f85b8
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07745646B2
연결된 노트
불러오는 중…