Potassium Carbonate → 3-[4-(2-Fluoroethyl)piperazin-1-YL]propan-1-OL
반응식
Br[CH2:2][CH2:3][CH2:4][OH:5].C(=O)([O-])[O-].[K+].[K+].OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.[F:26][CH2:27][CH2:28][N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>C(#N)C>[F:26][CH2:27][CH2:28][N:29]1[CH2:34][CH2:33][N:32]([CH2:2][CH2:3][CH2:4][OH:5])[CH2:31][CH2:30]1참가 물질
5
반응 조건
- 온도
- 85 °C
실험 절차
3-Bromopropan-1-ol (581 mg, 4.18 mmol) and potassium carbonate (2.88 g, 20.9 mmol) were added to a solution of 1-(2-fluoroethyl)-piperazine diTFA salt (1.5 g, 4.18 mmol) in acetonitrile (11 ml). The reaction mixture was stirred at 85° C. for 4 hours and then loaded directly onto a column and eluted with a mixture of methanol in methylene chloride (7/93) to give 3-[4-(2-fluoroethyl)piperazin-1-yl]propan-1-ol (721 mg, 91%).
후처리
- washeluted with a mixture of methanol in methylene chloride (7/93)
출처 및 근거
- ORD 기록
- ord-d0de446d37554ad5a054860ba179fadd
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08293902B2
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