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Cesium carbonate → N-(4-(7-(3-(1-hydroxycyclopropyl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide

HRID 2068226
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HRID 2068226 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([O:12][C:13]3[CH:18]=[CH:17][C:16]([N:19]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[C:20]([C:22]4([C:25]([NH2:27])=[O:26])[CH2:24][CH2:23]4)=[O:21])=[CH:15][C:14]=3[F:34])=[CH:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[O:35][CH3:36].CS(O[CH2:42][CH2:43][CH2:44][C:45]1([OH:48])[CH2:47][CH2:46]1)(=O)=O.C([O-])([O-])=O.[Cs+].[Cs+]>CC(N(C)C)=O>[OH:48][C:45]1([CH2:44][CH2:43][CH2:42][O:1][C:2]2[CH:11]=[C:10]3[C:5]([C:6]([O:12][C:13]4[CH:18]=[CH:17][C:16]([N:19]([C:28]5[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=5)[C:20]([C:22]5([C:25]([NH2:27])=[O:26])[CH2:24][CH2:23]5)=[O:21])=[CH:15][C:14]=4[F:34])=[CH:7][CH:8]=[N:9]3)=[CH:4][C:3]=2[O:35][CH3:36])[CH2:47][CH2:46]1
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참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 86640796HCID 86640796, 화합물HCID 136381441N-(3-fluoro-4-(7-hydroxy-6-methoxyquinolin-4-yloxy)phenyl)-N-phenylcyclopropane-1,1-dicarboxamide

생성물 1

HCID 68636414N-(4-(7-(3-(1-hydroxycyclopropyl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide

시약·촉매·용매 1

HCID 31374
Dimethylacetamide
용매

실험 절차

The title compound was prepared according to the procedure described in Example 9 by using N-(4-(7-hydroxy-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide (300 mg, 0.616 mmol), 3-(1-hydroxycyclopropyl)propyl methanesulfonate (155 mg, 0.80 mmol), and Cs2CO3 (602.5 mg, 1.848 mmol) in 3 mL of DMA. The residue was purified by a silical gel column chromatography (6:1 (v/v) EtOAc/n-hexane). The title compound was obtained as a white solid (263 mg, 73%).

후처리

  1. customThe title compound was prepared
  2. customThe residue was purified by a silical gel column chromatography (6:1 (v/v) EtOAc/n-hexane)

출처 및 근거

ORD 기록
ord-42be4a66973843779350a5684152c7ea
출처 데이터셋
uspto-grants-2012_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08293897B2

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