Ethyl 7-bromoheptanoate → 7-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)heptanoic acid
반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10]CC)=[O:9].[Cl:13][C:14]1[CH:15]=[N:16][CH:17]=[C:18]([Cl:35])[C:19]=1[NH:20][C:21]1[C:30]2[C:25](=[C:26]([OH:33])[C:27]([O:31][CH3:32])=[CH:28][CH:29]=2)[O:24][C:23](=[O:34])[CH:22]=1>>[Cl:13][C:14]1[CH:15]=[N:16][CH:17]=[C:18]([Cl:35])[C:19]=1[NH:20][C:21]1[C:30]2[C:25](=[C:26]([O:33][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9])[C:27]([O:31][CH3:32])=[CH:28][CH:29]=2)[O:24][C:23](=[O:34])[CH:22]=1참가 물질
3
실험 절차
The title compound was prepared from ethyl 7-bromoheptanoate and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedures outlined in Examples 25 & 42. 1H NMR (400 MHz, DMSO-d6): δ 9.50 (s, 1H), 8.81 (s, 2H), 7.94 (d, 1H), 7.19 (d, 1H), 4.63 (s, 1H), 3.97 (t, 2H), 3.91 (s, 3H), 2.19 (t, 2H), 1.66 (m, 2H), 1.54-1.40 (m, 4H), 1.31 (m, 2H); MS (ESI): 480.9.
출처 및 근거
- ORD 기록
- ord-ef71073614044396962468d2b7f9759d
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07745646B2
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