홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Ethanol → (R)-5,6-Dihydro-4H-benzo[F]imidazo[1,2-A]azepin-4-amine

HRID 2068538
노트
인쇄 미리보기

반응식

HRID 2068538 반응식
[CH:1]1[N:5]2[C:6]3[CH:25]=[CH:24][CH:23]=[CH:22][C:7]=3[CH2:8][CH2:9][C@@H:10]([NH:11]C(=O)OCC3C=CC=CC=3)[C:4]2=[N:3][CH:2]=1.C(O)C>[Pd]>[CH:1]1[N:5]2[C:6]3[CH:25]=[CH:24][CH:23]=[CH:22][C:7]=3[CH2:8][CH2:9][C@@H:10]([NH2:11])[C:4]2=[N:3][CH:2]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 702EthanolHCID 58304077benzyl N-[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamate

생성물 1

HCID 58304055(R)-5,6-Dihydro-4H-benzo[F]imidazo[1,2-A]azepin-4-amine수율 100.4%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

Dissolve benzyl N-[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamate (6.95 g, 20.85 mmol) in absolute ethanol (375 mL, 6.44 moles) and add 10% palladium on carbon (Pd/C) (0.70 g, 6.57 mmol). Place the mixture on a Parr shaker under Hydrogen (H2) for 7 hours (60 psi, ambient temperature). Remove the catalyst by filtration and concentrate the filtrate under reduced pressure to give the title compound (4.17 g, 100%) as a yellow solid: MS (m/z): 200 (M+1).

후처리

  1. customfor 7 hours
  2. custom(60 psi, ambient temperature)
  3. customRemove the catalyst
  4. filtrationby filtration
  5. concentrationconcentrate the filtrate under reduced pressure

출처 및 근거

ORD 기록
ord-db1c66b637034b93b8e2d09dda25272c
출처 데이터셋
uspto-grants-2012_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08299061B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트