Water → 7-Bromo-2-(2-hydroxyethyl)-isoquinolin-1-one
반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:20][CH2:21][OH:22].O>CN(C)C=O>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]([CH2:20][CH2:21][OH:22])[C:9]2=[O:12])=[CH:4][CH:3]=1참가 물질
6
실험 절차
A solution of compound 5 (19.8 g, 88.4 mmol), potassium carbonate (18.3 g, 133 mmol) and 2-bromoethanol (13.3 g, 106 mmol) in dimethylforamide (200 mL) was stirred at 80° C. for 12 h. Then the mixture was cooled to room temperature and poured into water. The mixture was extracted with ethyl acetate (three times 500 mL), dried (sodium sulfate), concentrated and purified by chromatography on silica gel to give 6 (16.2 g, 68%)
후처리
- extractionThe mixture was extracted with ethyl acetate (three times 500 mL)
- dry with materialdried (sodium sulfate)
- concentrationconcentrated
- custompurified by chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-a2dd00f879784a5797fb0676e3ae4eac
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08299023B2
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