Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 5-Oxazol-4-yl-thiophene-3-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 5-Oxazol-4-yl-thiophene-3-carboxylic acid methyl ester | HCID 58110244 | — |
| 생성물 | 5-Oxazol-4-yl-thiophene-3-carboxylic acid | HCID 58110221 | 100.2% |
반응 단계
5-Oxazol-4-yl-thiophene-3-carboxylic acid methyl ester (0.049 g, 0.23 mmol) was suspended in IMS (1 mL), sodium hydroxide (1 M, 0.35 mL) was added and the mixture stirred for 60 hours at room temperature. The mixture was quenched with HCl (1 N, 0.35 mL) and then concentrated, azeotroping twice with methanol to afford 5-oxazol-4-yl-thiophene-3-carboxylic acid as a white solid (0.045 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08299063B2 |
| 출처 데이터셋 | uspto-grants-2012_10 |
| ORD ID | ord-a9e15b923af248999376c9b186edc511 |
| 출처 메모 | uspto-grants-2012_10 |