Dimethylacetamide → 1-Cyclohexyl-7-(3-methyl-[1,2,4]-oxadiazol-5-yl)imidazo-[1,5-a]quinoxalin-4(5H)-one

HRID 2068950노트

반응식

HRID 2068950 반응식
[CH:1]1([C:7]2[N:11]3[C:12]4[C:17]([NH:18][C:19](=[O:20])[C:10]3=[CH:9][N:8]=2)=[CH:16][C:15]([C:21]([OH:23])=O)=[CH:14][CH:13]=4)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CN(C)C(=O)C.C(N1C=CN=C1)(N1C=CN=C1)=O.O[NH:43][C:44](=[NH:46])[CH3:45]>O>[CH:1]1([C:7]2[N:11]3[C:12]4[C:17]([NH:18][C:19](=[O:20])[C:10]3=[CH:9][N:8]=2)=[CH:16][C:15]([C:21]2[O:23][N:46]=[C:44]([CH3:45])[N:43]=2)=[CH:14][CH:13]=4)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

6

반응물 4

HCID 31374DimethylacetamideHCID 682631,1'-CarbonyldiimidazoleHCID 591986821-Cyclohexyl-4-oxo-4,5-dihydroimidazo[1,5-a]quinoxaline-7-carboxylic acidHCID 178465666HCID 178465666, 화합물

생성물 1

HCID 591987781-Cyclohexyl-7-(3-methyl-[1,2,4]-oxadiazol-5-yl)imidazo-[1,5-a]quinoxalin-4(5H)-one

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1-Cyclohexyl-4-oxo-4,5-dihydroimidazo[1,5-a]quinoxaline-7-carboxylic acid as synthesized in Example 58, 300 mg, N,N-dimethylacetamide 5 mL and 1,1′-carbonyldiimidazole 266 mg were mixed and stirred for 30 minutes at room temperature. To the reaction liquid 143 mg of N-hydroxyacetamidine was added, followed by 12 hours' stirring at 110° C. After returning it to the room temperature, water was added thereto and the precipitated matter was recovered by filtration. Drying the precipitate by heating under reduced pressure, 210 mg of the title compound was obtained.

후처리

  1. additionwere mixed
  2. additionwas added
  3. waitfollowed by 12 hours
  4. stirring' stirring at 110° C
  5. additionwas added
  6. filtrationthe precipitated matter was recovered by filtration
  7. customDrying the precipitate
  8. temperatureby heating under reduced pressure

출처 및 근거

ORD 기록
ord-2b6ac6dbd90d4fd3966a003b2a024e89
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299080B2

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