Acetic Acid → Ethyl 3-(7-ethyl-4-oxo-4,5-dihydroimidazo[1,5-a]quinoxalin-1-yl)propanoate

HRID 2068956노트

반응식

HRID 2068956 반응식
[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]1[C:14]([CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[N:15][CH:16]=[C:9]1[C:8](=[O:24])[NH:7]2)(=O)[CH3:2].C(O)(=O)C>[OH-].[OH-].[Pd+2].[H][H]>[CH2:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]1[C:14]([CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[N:15][CH:16]=[C:9]1[C:8](=[O:24])[NH:7]2)[CH3:2]

참가 물질

5

반응물 2

HCID 176Acetic AcidHCID 59198600Ethyl 3-(7-acetyl-4-oxo-4,5-dihydroimidazo[1,5-a]-quinoxalin-1-yl)propanoate

생성물 1

HCID 59198574Ethyl 3-(7-ethyl-4-oxo-4,5-dihydroimidazo[1,5-a]quinoxalin-1-yl)propanoate

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매2회HCID 178418361HCID 178418361, 화합물용매

실험 절차

A mixture of ethyl 3-(7-acetyl-4-oxo-4,5-dihydroimidazo[1,5-a]-quinoxalin-1-yl)propanoate as synthesized in above Example 183, 131 mg, Pearlman's catalyst 100 mg and acetic acid 5 mL was stirred in hydrogen atmosphere at room temperature for 43 hours. Then 75 mg of Pearlman's catalyst was added and the reaction liquid was mildly heated. Twenty-two hours later, the reaction liquid was filtered through Celite, and 30 mL of water was added to the filtrate. The precipitate was recovered by filtration, washed with water and dried in flowing air under heating to provide 65 mg of the title compound.

후처리

  1. customthe reaction liquid
  2. temperaturewas mildly heated
  3. customTwenty-two hours later, the reaction liquid
  4. filtrationwas filtered through Celite, and 30 mL of water
  5. additionwas added to the filtrate
  6. filtrationThe precipitate was recovered by filtration
  7. washwashed with water
  8. customdried
  9. temperatureunder heating

출처 및 근거

ORD 기록
ord-1f9ff0a304384bfbbfe4018c879cc0dd
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299080B2

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