Piperidine → Ethyl 5-[(E)-2-ethoxycarbonylvinyl]-3-methyl-1H-pyrrole-2-carboxylate

HRID 2068984

반응식

HRID 2068984 반응식
[CH:1]([C:3]1[NH:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:13])[CH:4]=1)=O.[C:14]([O:20][CH2:21][CH3:22])(=[O:19])[CH2:15]C([O-])=O.N1CCCCC1>N1C=CC=CC=1>[CH2:21]([O:20][C:14](/[CH:15]=[CH:1]/[C:3]1[NH:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:13])[CH:4]=1)=[O:19])[CH3:22]

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 1113514ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxylateHCID 3595298Propanedioic acid, monoethyl ester

생성물 1

HCID 59198650Ethyl 5-[(E)-2-ethoxycarbonylvinyl]-3-methyl-1H-pyrrole-2-carboxylate수율 47.7%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
100 °C

실험 절차

Ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxylate 470 mg, monoethyl malonate 378 mg, piperidine 0.05 mL and pyridine 6 mL were mixed and stirred at 100° C. for 38 hours. Ice water was added to the reaction liquid and the precipitate was recovered by filtration. The precipitate was washed with water and dried in flowing air under heating to provide 311 mg of the title compound.

후처리

  1. filtrationthe precipitate was recovered by filtration
  2. washThe precipitate was washed with water
  3. customdried
  4. temperatureunder heating

출처 및 근거

ORD 기록
ord-03e6a0fb06e24cdfbdfa2e6c1dfb14ae
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299080B2

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