Lawesson's reagent → (1-{4-[5-(4-Butoxyphenyl)-[1,3,4]thiadiazol-2-yl]phenyl}pyrrolidin-3-yl)dimethylamine

HRID 2069323

반응식

HRID 2069323 반응식
[CH2:1]([O:5][C:6]1[CH:31]=[CH:30][C:9]([C:10]([NH:12][NH:13][C:14](=O)[C:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH2:25][CH2:24][CH:23]([N:26]([CH3:28])[CH3:27])[CH2:22]3)=[CH:17][CH:16]=2)=O)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:41])=CC=1>C1(C)C=CC=CC=1>[CH2:1]([O:5][C:6]1[CH:31]=[CH:30][C:9]([C:10]2[S:41][C:14]([C:15]3[CH:20]=[CH:19][C:18]([N:21]4[CH2:25][CH2:24][CH:23]([N:26]([CH3:28])[CH3:27])[CH2:22]4)=[CH:17][CH:16]=3)=[N:13][N:12]=2)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 87949Lawesson's reagentHCID 69208757N'-(4-butoxybenzoyl)-4-(3-dimethylaminopyrrolidin-1-yl)benzohydrazide

생성물 1

HCID 59643599(1-{4-[5-(4-Butoxyphenyl)-[1,3,4]thiadiazol-2-yl]phenyl}pyrrolidin-3-yl)dimethylamine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of N′-(4-butoxybenzoyl)-4-(3-dimethylaminopyrrolidin-1-yl)benzo-hydrazide (100 mg), Lawesson's reagent (191 mg) and toluene (5 ml) was boiled under reflux for 4 hours. Volatiles were removed, and the residue was purified by preparative HPLC. The product with the molecular weight of 422.60 (C24H30N4OS) was obtained in this way; MS (ESI): 423 (M+H+).

후처리

  1. temperatureunder reflux for 4 hours
  2. customVolatiles were removed
  3. customthe residue was purified by preparative HPLC
  4. customThe product with the molecular weight of 422.60 (C24H30N4OS) was obtained in this way

출처 및 근거

ORD 기록
ord-dfbd82e34d6d4f79872b56ea26d3905c
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299104B2

연결된 노트

불러오는 중…