Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Butoxybenzoic acid → N'-(4-butoxybenzoyl)-4-(3-dimethylaminopyrrolidin-1-yl)benzohydrazide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Butoxybenzoic acid | HCID 72971 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| 반응물 | 4-(3-Dimethylaminopyrrolidin-1-yl)benzohydrazide | HCID 69213108 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N'-(4-butoxybenzoyl)-4-(3-dimethylaminopyrrolidin-1-yl)benzohydrazide | HCID 69208757 | — |
반응 단계
A mixture of 4-butoxybenzoic acid (156 mg) and DMF (10 ml) was mixed with TOTU (264 mg) and N,N-diisopropylethylamine (104 mg). After 10 minutes, 4-(3-dimethylaminopyrrolidin-1-yl)benzohydrazide (200 mg) was added. After one hour, the mixture was diluted with water and extracted with ethyl acetate. The organic phase was washed with water, dried over magnesium sulfate, filtered and concentrated. The product with the molecular weight of 424.55 (C24H32N4O3) was obtained in this way; MS (ESI): 425 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08299104B2 |
| 출처 데이터셋 | uspto-grants-2012_10 |
| ORD ID | ord-a46ea26eb7344cf78e64e0e56da54b45 |
| 출처 메모 | uspto-grants-2012_10 |