Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylamine → 4-(3,5-dichloropyridin-4-ylamino)-8-(6-(dimethylamino)hexyloxy)-7-methoxy-2H-chromen-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylamine | HCID 674 | — |
| 반응물 | 1,6-Dibromohexane | HCID 12368 | — |
| 반응물 | 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one | HCID 24849570 | — |
| 생성물 | 4-(3,5-dichloropyridin-4-ylamino)-8-(6-(dimethylamino)hexyloxy)-7-methoxy-2H-chromen-2-one | HCID 24849255 | — |
반응 단계
The title compound was prepared from dimethylamine, 1,6-dibromohexane, and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedures outlined in Examples 25 & 27. 1H NMR (400 MHz, DMSO-d6): δ 9.38 (br s, 1H), 8.57 (s, 2H), 7.85 (d, 1H), 7.05 (d, 1H), 4.24 (br s, 1H), 3.96 (t, 2H), 3.87 (s, 3H), 2.55 (br, 2H), 2.37 (s, 6H), 1.67 (m, 2H), 1.49 (m, 4H), 1.34 (m, 2H); MS (ESI): 479.9.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745646B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-1facfed5f0794cea8bcd6e434d1de8e3 |
| 출처 메모 | uspto-grants-2010_06 |