반응식
[CH3:1][NH:2][CH3:3].Br[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]Br.[Cl:13][C:14]1[CH:15]=[N:16][CH:17]=[C:18]([Cl:35])[C:19]=1[NH:20][C:21]1[C:30]2[C:25](=[C:26]([OH:33])[C:27]([O:31][CH3:32])=[CH:28][CH:29]=2)[O:24][C:23](=[O:34])[CH:22]=1>>[Cl:13][C:14]1[CH:15]=[N:16][CH:17]=[C:18]([Cl:35])[C:19]=1[NH:20][C:21]1[C:30]2[C:25](=[C:26]([O:33][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:2]([CH3:3])[CH3:1])[C:27]([O:31][CH3:32])=[CH:28][CH:29]=2)[O:24][C:23](=[O:34])[CH:22]=1참가 물질
4
실험 절차
The title compound was prepared from dimethylamine, 1,7-dibromoheptane, and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedures outlined in Examples 25 & 27. 1H NMR (400 MHz, DMSO-d6): δ 9.38 (br s, 1H), 8.58 (s, 2H), 7.85 (d, 1H), 7.05 (d, 1H), 4.26 (br s, 1H), 3.96 (t, 2H), 3.87 (s, 3H), 2.51 (br, 2H), 2.35 (s, 6H), 1.67 (m, 2H), 1.46 (m, 4H), 1.30 (m, 4H); MS (ESI): 493.9.
출처 및 근거
- ORD 기록
- ord-c353dfc6688d4b1f936f032200b1b169
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07745646B2
연결된 노트
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