(E)-ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)acrylate → Ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)propanoate

HRID 2069637

반응식

HRID 2069637 반응식
[OH:1][C:2]1[CH:3]=[CH:4][C:5](/[CH:14]=[CH:15]/[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[H][H]>C(O)C.[Pd]>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1

참가 물질

5

반응물 2

HCID 58566652(E)-ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)acrylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 58566596Ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)propanoate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution (E)-ethyl 3-(5-hydroxy-[1,1′-biphenyl]-2-yl)acrylate (652) (420 mg, 1.57 mmol) in ethanol (6 mL) was added Pd/C (42 mg, 10% Degussa type). A balloon of hydrogen gas was added and the reaction was evacuated and back-filled with hydrogen three times. The reaction was stirred overnight at room temperature, was filtered through a pad of celite and concentrated in vacuo to give ethyl 3-(5-hydroxy-[1,1′-biphenyl]-2-yl)propanoate (653).

후처리

  1. customthe reaction was evacuated
  2. additionback-filled with hydrogen three times
  3. filtrationwas filtered through a pad of celite
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-3a5b2a2f2de44eb3b1047e593d8ab2fe
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299117B2

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