Dimethylamine → 6-(Dimethylamino)-1,2-dihydroisoquinolin-1-one

HRID 2069743

반응식

HRID 2069743 반응식
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[CH:5]2.[CH3:13][NH:14][CH3:15]>C(O)C>[CH3:13][N:14]([CH3:15])[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[CH:5]2

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 450908026-Fluoroisoquinolin-1(2H)-one

생성물 1

HCID 574241426-(Dimethylamino)-1,2-dihydroisoquinolin-1-one

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
150 °C

실험 절차

6-Fluoro-2H-isoquinolin-1-one (54 mg, 0.33 mmol) was deposited in a sealed tube with 5 mL 33% dimethylamine in ethanol. This was heated at 150° C. for 3.5 hours. This was concentrated in vacuo and purified by flash chromatography (gradient elution 50 to 100% ethyl acetate/hexanes) to yield 6-Dimethylamino-2H-isoquinolin-1-one (39 mg, 0.21 mmol). MS (ESI) 189.1 (M+H)−.

후처리

  1. concentrationThis was concentrated in vacuo
  2. custompurified by flash chromatography (gradient elution 50 to 100% ethyl acetate/hexanes)

출처 및 근거

ORD 기록
ord-45bdd3b449d544b8801d551331c06025
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299077B2

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