Dichloromethane → Valine methyl ester

반응식

Cl.[NH2:2][C@H:3]([C:7]([OH:9])=[O:8])[CH:4]([CH3:6])[CH3:5].Cl[CH2:11]Cl>>[CH3:11][O:8][C:7](=[O:9])[C@H:3]([CH:4]([CH3:6])[CH3:5])[NH2:2]

참가 물질

반응물 2

HCID 6344Dichloromethane

HCID 13000930L-Valine, hydrochloride (1:1)

생성물 1

HCID 94285Valine methyl ester

실험 절차

500 mg of methyl ester of L-(+)-valine hydrochloride are placed in a round-bottom flask. 45 mL of buffer solution (K2HPO4/K3PO4 (pH=12.4)), then 22.5 mL of anhydrous dichloromethane are successively added. The mixture is agitated at room temperature for 30 min. The organic phase is separated, washed with brine, dried on magnesium sulfate, filtered and concentrated under vacuum.

후처리

customThe organic phase is separated
washwashed with brine
customdried on magnesium sulfate
filtrationfiltered
concentrationconcentrated under vacuum

출처 및 근거

ORD 기록: ord-21885dc629d74c55b99e3a5e8f9ffdb8
출처 데이터셋: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08299250B2

반응 노트

불러오는 중…