Acetic Acid → 6-(4-Chlorophenyl)-2,3-dihydropyridazin-3-one

HRID 2070

반응식

HRID 2070 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.C(O)(=O)C.BrBr>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 24408BromineHCID 1209906-(4-Chlorophenyl)-4,5-Dihydropyridazin-3(2H)-One

생성물 1

HCID 6890856-(4-Chlorophenyl)-2,3-dihydropyridazin-3-one수율 93.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 6-(4-chlorophenyl)-4,5-dihydropyridazinone (11.75 g) and glacial acetic acid (100 ml) was added dropwise 3 ml of bromine and the mixture was heated at 60°-70° C. for 3 h. The resulting mixture was cooled and slowly poured into 400 ml of cold water. The resulting white solid was filtered and dried to yield 10.83 g (89%) of 6-(4-chlorophenyl)pyridazinone.

후처리

  1. temperaturethe mixture was heated at 60°-70° C. for 3 h
  2. temperatureThe resulting mixture was cooled
  3. filtrationThe resulting white solid was filtered
  4. customdried

출처 및 근거

ORD 기록
ord-5f7f1d1943894178b387870f0ce435aa
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728694

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