4-[1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy]aniline → 4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)aniline

HRID 2070026노트

반응식

HRID 2070026 반응식
COC1C=CC(C[N:8]2[C:12]3=[N:13][CH:14]=[CH:15][C:16]([O:17][C:18]4[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=4)=[C:11]3[CH:10]=[N:9]2)=CC=1>C(O)(C(F)(F)F)=O>[NH:8]1[C:12]2=[N:13][CH:14]=[CH:15][C:16]([O:17][C:18]3[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=3)=[C:11]2[CH:10]=[N:9]1

참가 물질

3

반응물 1

HCID 593985274-[1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy]aniline

생성물 1

HCID 593985424-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)aniline수율 88%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

반응 조건

온도
60 °C

실험 절차

4-[1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy]aniline (263 mg) was dissolved in TFA (7.5 mL). The resulting mixture was stirred at 60° C. for 2 hours and concentrated under reduced pressure. The residue was diluted with dichloromethane and then washed with a sodium bicarbonate solution and saturated brine. The organic layer was separated and concentrated under reduced pressure. The residue was suspended in ether, and the precipitate was collected by filtration to give 4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)aniline (151 mg, yield: 88%) as a light-brown powder.

후처리

  1. concentrationconcentrated under reduced pressure
  2. additionThe residue was diluted with dichloromethane
  3. washwashed with a sodium bicarbonate solution and saturated brine
  4. customThe organic layer was separated
  5. concentrationconcentrated under reduced pressure
  6. filtrationthe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-83cd822d725c415caa649f5eb6e79c20
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299252B2

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