Water → HCID 68587480, 화합물

HRID 2070236노트

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HRID 2070236 반응식
[C:1]([C:5]1[CH:6]=[C:7]([OH:11])[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Cl[C:13]1[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][C:16]([N+:23]([O-:25])=[O:24])=[C:15]([CH3:26])[CH:14]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[C:1]([C:5]1[CH:6]=[C:7]([CH:8]=[CH:9][CH:10]=1)[O:11][C:13]1[C:18]([C:19]([F:20])([F:22])[F:21])=[CH:17][C:16]([N+:23]([O-:25])=[O:24])=[C:15]([CH3:26])[CH:14]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 11450Phenol, 3-(1,1-dimethylethyl)-HCID 210179751-Chloro-5-methyl-4-nitro-2-(trifluoromethyl)benzene

생성물 1

HCID 68587480HCID 68587480, 화합물수율 72%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In 50 ml of N,N-dimethylformamide, 3.00 g (19.97 mmol) of 3-tertbutylphenol, 4.35 g (18.16 mmol) of 4-chloro-5-trifluoromethyl-2-methylnitrobenzene and 3.26 g (23.60 mmol) of potassium carbonate are heated at 50° C. for 15 min. The reaction solution is added to water and extracted repeatedly with dichloromethane, the extracts are dried over Na2SO4 and filtered and the solvent is removed under reduced pressure. The solid is washed with water and hexane and dried under reduced pressure. (6.6 g, purity 70.0%, yield 72.0%, log P (pH 2.3)=5.68).

후처리

  1. extractionextracted repeatedly with dichloromethane
  2. dry with materialthe extracts are dried over Na2SO4
  3. filtrationfiltered
  4. customthe solvent is removed under reduced pressure
  5. washThe solid is washed with water and hexane
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-51a2b8c425b44971bcf466b0d7d814bf
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299301B2

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