Tert-butyl 4-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-5-yloxy}pyridine-2-carboxylate → HCID 22040646, 화합물

HRID 2070251

반응식

HRID 2070251 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:13]([CH3:14])[C:12]3[CH:15]=[CH:16][C:17]([O:19][C:20]4[CH:25]=[CH:24][N:23]=[C:22]([C:26]([O:28]C(C)(C)C)=[O:27])[CH:21]=4)=[CH:18][C:11]=3[N:10]=2)=[CH:4][CH:3]=1>FC(F)(F)C(O)=O.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:13]([CH3:14])[C:12]3[CH:15]=[CH:16][C:17]([O:19][C:20]4[CH:25]=[CH:24][N:23]=[C:22]([C:26]([OH:28])=[O:27])[CH:21]=4)=[CH:18][C:11]=3[N:10]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 22041284Tert-butyl 4-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-5-yloxy}pyridine-2-carboxylate

생성물 1

HCID 22040646HCID 22040646, 화합물

시약·촉매·용매 2

HCID 962Water촉매HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of the product of step 7 in trifluoroacetic acid was treated with two drops of water at room temperature for 3-4 hours or until the reaction was determined to be complete by HPLC. The reaction was evaporated under reduced pressure to afford the product as a red-orange oil in quantitative yield. MS: MH+=439.

후처리

  1. customThe reaction was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e771972dfba642509c96377917b5c6dd
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299108B2

연결된 노트

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