참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Methyl-5-Nitroaniline | HCID 7444 | — |
| 반응물 | 1,2-Dibromobutane | HCID 10792 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (2-Methyl-5-nitrophenyl)pyrrolidine | HCID 69558510 | — |
반응 단계
To the mixture containing 2-methyl-5-nitrophenylamine and potassium carbonate (4 eq) in dimethyl formamide was added 1,2 dibromobutane (4 eq) and the resulting mixture was stirred at 70° C. for 16 hours. The reaction mixture was then concentrated and partitioned between ethyl acetate and water. The organic layer was dried with sodium sulfate and concentrated and purified on silica gel to give (2-methyl-5-nitrophenyl)pyrrolidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08299108B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_10 |
|---|
| ORD ID | ord-94369907dd7b4e7a88b5b3955fb666d3 |
|---|
| 출처 메모 | uspto-grants-2012_10 |
|---|
