Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzenesulfonic acid, 3-nitro-, (2R)-2-oxiranylmethyl ester → N-Cyclopropyl-3-fluoro-4-methyl-5-[3-({1-methyl-1-[2-(2R)-(oxiran-2-ylmethoxy)phenyl]ethyl}amino)-2-oxopyrazin-1(2H)-yl]benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzenesulfonic acid, 3-nitro-, (2R)-2-oxiranylmethyl ester | HCID 146513 | — |
| 반응물 | HCID 66689080 | HCID 66689080 | — |
| 생성물 | N-Cyclopropyl-3-fluoro-4-methyl-5-[3-({1-methyl-1-[2-(2R)-(oxiran-2-ylmethoxy)phenyl]ethyl}amino)-2-oxopyrazin-1(2H)-yl]benzamide | HCID 86663255 | — |
반응 단계
Prepared from N-cyclopropyl-3-fluoro-5-[3-[[1-(2-hydroxyphenyl)-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide (Example 252j) and (R)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate, using a similar method to that described in Example 299a.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08299246B2 |
| 출처 데이터셋 | uspto-grants-2012_10 |
| ORD ID | ord-43bf2efc1e474c179a24900975f7dfb3 |
| 출처 메모 | uspto-grants-2012_10 |