Aluminium lithium hydride → (4-Isopropylpyridin-2-yl)methanamine
반응식
[CH:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]#[N:11])[CH:5]=1)([CH3:3])[CH3:2].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([CH2:10][NH2:11])[CH:5]=1)([CH3:3])[CH3:2]참가 물질
4
실험 절차
To a stirring solution of 149 mg (1.01 mmol) of 4-isopropylpicolinonitrile in 7 mL of THF at 0° C. was added 150 mg (3.95 mmol) of LiAlH4. After about 15 min., 250 mg of LiAlH4 was added, and after about 15 min. the ice bath was removed and stirring was continued with warming to r.t. After 40 min., 400 μL of H2O, 400 μL of 15% NaOH (aq), and 1.2 mL of brine were added in succession. The mixture was stirred for 85 min., filtered through Celite, and conc. to give 143 mg of (4-isopropylpyridin-2-yl)methanamine which was used without further purification.
후처리
- customafter about 15 min. the ice bath was removed
- waitAfter 40 min.
- addition400 μL of H2O, 400 μL of 15% NaOH (aq), and 1.2 mL of brine were added in succession
- stirringThe mixture was stirred for 85 min.
- filtrationfiltered through Celite
출처 및 근거
- ORD 기록
- ord-c080f00cdb3448cca8d7c3720b23e52e
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08299267B2
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