Benzene → HCID 86733624, 화합물

HRID 2071209노트

반응식

HRID 2071209 반응식
[CH2:1]([C:4]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:5]=1[NH:6][CH2:7][CH:8]=[O:9])[CH2:2][CH3:3].C(=O)([O-])[O-].[Na+].[Na+].C1C=CC=CC=1.[Cl:27][CH2:28][C:29](Cl)=[O:30]>O>[Cl:27][CH2:28][C:29]([N:6]([CH2:7][CH:8]=[O:9])[C:5]1[CH:10]=[C:11]([F:14])[CH:12]=[CH:13][C:4]=1[CH2:1][CH2:2][CH3:3])=[O:30]

참가 물질

6

반응물 4

HCID 241BenzeneHCID 6577Chloroacetyl chlorideHCID 10340Sodium CarbonateHCID 21412830HCID 21412830, 화합물

생성물 1

HCID 86733624HCID 86733624, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The dimethyl acetal of 2-(2-propyl-5-fluoroanilino)-acetaldehyde (0.1 mole), sodium carbonate (0.06 mole) dissolved in water (50 ml) and benzene (50 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and cooling means. The mixture is cooled to a temperature of about 0° C. and α-chloroacetyl chloride (0.11 mole) is incrementally added with stirring. After the addition is completed stirring is continued and the reaction mixture is permitted to warm to room temperature. After this time the mixture is filtered, washed with dilute hydrochloric acid and stripped of solvent to yield the desired product the dimethyl acetal of 2-(N-α-chloroacetyl-2-propyl-5-fluoroanilino)acetaldehyde.

후처리

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and cooling means
  3. additionis incrementally added
  4. additionAfter the addition
  5. stirringis completed stirring
  6. filtrationAfter this time the mixture is filtered
  7. washwashed with dilute hydrochloric acid

출처 및 근거

ORD 기록
ord-d7803314caaa451eb0c5d644f6b7dbda
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04046554

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