Dimethylformamide → HCID 18594803, 화합물

HRID 2071340노트

반응식

HRID 2071340 반응식
CS(O[CH:6]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:7][CH2:8][C@@H:9]1[C@@H:13]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:12](=[O:25])[CH2:11][CH2:10]1)(=O)=O.CN(C)C=O.[Cl-:36].[Li+]>O>[Cl:36][CH:6]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:7][CH2:8][C@@H:9]1[C@@H:13]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:12](=[O:25])[CH2:11][CH2:10]1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 433294Lithium ChlorideHCID 18594876HCID 18594876, 화합물

생성물 1

HCID 18594803HCID 18594803, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 1.35 g. of ethyl 15-methanesulfonyloxy 9-oxo-prostanoate (Example 90) in 40 ml. of N,N-dimethylformamide containing 650 mg. of lithium chloride is heated on the steam bath for 18 hours. The cooled solution is diluted with water and the resulting mixture is extracted with ether. The ether extract is washed with saline, dried with saline, dried with anhydrous magnesium sulfate and evaporated to dryness to give an oil. Chromatography on silica gel affords an oil; λ max. 5.78 μ (carbonyl groups).

후처리

  1. extractionthe resulting mixture is extracted with ether
  2. extractionThe ether extract
  3. washis washed with saline
  4. customdried with saline
  5. dry with materialdried with anhydrous magnesium sulfate
  6. customevaporated to dryness
  7. customto give an oil
  8. customChromatography on silica gel affords an oil

출처 및 근거

ORD 기록
ord-7428934710db44b2aa3a2c48e94d734f
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04046787

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