Methylamine → HCID 70625931, 화합물

HRID 2071641노트

반응식

HRID 2071641 반응식
[Cl:1][C:2]1[C:3]2[C:4](=[N:14][N:15]([CH3:17])[CH:16]=2)[N:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[CH3:18][NH2:19]>>[ClH:1].[CH3:18][NH:19][C:2]1[C:3]2[C:4](=[N:14][N:15]([CH3:17])[CH:16]=2)[N:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[CH3:18][N:14]1[C:4]2=[N:5][C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[CH:7][CH:2]=[C:3]2[CH2:16][N:15]1[CH3:17]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 22756855HCID 22756855, 화합물

생성물 2

HCID 70625931HCID 70625931, 화합물HCID 131710884HCID 131710884, 화합물

실험 절차

17 g. of 4-chloro-2-methyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine (0.07 mol.) and 60 ml. of alcoholic methylamine (270 g/l) are heated at 150°-160° in an autoclave for four hours. After cooling to room temperature, the solution is evaporated in vacuo and the residue is extracted with chloroform. To the chloroform extract is added ethereal hydrochloric acid to give the crude hydrochloride of N,2-dimethyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine which, after treatment with ether, becomes crystalline.

후처리

  1. customthe solution is evaporated in vacuo
  2. extractionthe residue is extracted with chloroform
  3. extractionTo the chloroform extract
  4. additionis added ethereal hydrochloric acid

출처 및 근거

ORD 기록
ord-9eb8b0dd18c24d4cb5beafbeb06afd0f
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04048184

반응 노트

불러오는 중…