4-Isopropoxycarbonylamino-2-nitroaniline → 1,2-Diamino-4-isopropoxycarbonylaminobenzene

HRID 2071797노트

반응식

HRID 2071797 반응식
[N+:1]([C:4]1[CH:10]=[C:9]([NH:11][C:12]([O:14][CH:15]([CH3:17])[CH3:16])=[O:13])[CH:8]=[CH:7][C:5]=1[NH2:6])([O-])=O.[H][H]>CO.[Pt]=O>[NH2:6][C:5]1[CH:7]=[CH:8][C:9]([NH:11][C:12]([O:14][CH:15]([CH3:16])[CH3:17])=[O:13])=[CH:10][C:4]=1[NH2:1]

참가 물질

5

반응물 2

HCID 126780374-Isopropoxycarbonylamino-2-nitroanilineHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 126780381,2-Diamino-4-isopropoxycarbonylaminobenzene수율 66.3%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 887Methanol용매

실험 절차

A mixture of a solution of 2-nitro-4-isopropoxycarbonylaminoaniline (17.9 g, 0.075 mole) in methanol (450 ml) and platinum oxide (1.0 g) was shaken in an atmosphere of hydrogen at atmospheric pressure and laboratory temperature for several hours, during which time 5.04 liters of hydrogen were absorbed. The mixture was filtered, and the methanol removed in vacuo and the dark solid residue recrystallised from benzene to give 1,2-diamino-4-isopropoxycarbonylaminobenzene (10.4 g), m.p. 108°-110° C.

후처리

  1. customwere absorbed
  2. filtrationThe mixture was filtered
  3. customthe methanol removed in vacuo
  4. customthe dark solid residue recrystallised from benzene

출처 및 근거

ORD 기록
ord-22ab45fac708435cae7f3fe6b69fef14
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04048326

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