3-[4-(Propan-2-yl)cyclohexyl]propanoic acid → 1,5-Bis[4-(propan-2-yl)cyclohexyl]pentan-3-one

HRID 2071875노트

반응식

HRID 2071875 반응식
[CH:1]([CH:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12]([OH:14])=O)[CH2:6][CH2:5]1)([CH3:3])[CH3:2]>[Fe]>[CH:1]([CH:4]1[CH2:5][CH2:6][CH:7]([CH2:10][CH2:11][C:12](=[O:14])[CH2:11][CH2:10][CH:7]2[CH2:6][CH2:5][CH:4]([CH:1]([CH3:2])[CH3:3])[CH2:9][CH2:8]2)[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

참가 물질

3

반응물 1

HCID 213966513-[4-(Propan-2-yl)cyclohexyl]propanoic acid

생성물 1

HCID 213966471,5-Bis[4-(propan-2-yl)cyclohexyl]pentan-3-one

시약·촉매·용매 1

HCID 23925Iron촉매

반응 조건

온도
290 °C

실험 절차

3-(4-Isopropylcyclohexyl)propionic acid (39.7 g., 0.20 mole) and iron (hydrogen reduced, 6.15 g., 0.11 mole) is heated for 1.5 hours at 195° C. under a nitrogen atmosphere. After that time, the temperature is increased to 290° C. and maintained at that temperature for three hours. The cooled reaction mass is extracted well with ether, filtered through Celite, and the ethereal extracts concentrated under vacuum. The residue is stripped under vacuum to leave the product, 17.3 g. (51%).

후처리

  1. temperaturemaintained at that temperature for three hours
  2. customThe cooled reaction mass
  3. extractionis extracted well with ether
  4. filtrationfiltered through Celite
  5. concentrationthe ethereal extracts concentrated under vacuum
  6. customto leave the product, 17.3 g

출처 및 근거

ORD 기록
ord-b0f943ad6dc84a02889d4cc46b1df853
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04049417

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