Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,6-Dimethoxypyrimidine-5-carbaldehyde → 2,6-Diamino-4-(4,6-dimethoxypyrimid-5-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,6-Dimethoxypyrimidine-5-carbaldehyde | HCID 4436645 | — |
| 반응물 | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2,6-Diamino-4-(4,6-dimethoxypyrimid-5-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70631685 | 56% |
반응 단계
Upon heating a solution of 8.4 g 4,6-dimethoxypyrimidine-5-aldehyde and 13.0 g amidinoacetic acid ethyl ester in 150 ml ethanol for 2 hours, 2,6-diamino-4-(4,6-dimethoxypyrimid-5-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of m.p. 219° C. (ethanol) is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04049662 |
| 출처 데이터셋 | uspto-grants-1977_09 |
| ORD ID | ord-84c4d1be26fa4df0a5d3cb03168ce90e |
| 출처 메모 | uspto-grants-1977_09 |