Water → HCID 86733843, 화합물

HRID 2072004노트

반응식

HRID 2072004 반응식
[CH2:1]([CH2:8][NH:9][C:10]([CH3:14])([CH3:13])[C:11]#[N:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O>CCOCC>[CH2:1]([CH2:8][NH:9][C:10]([CH3:14])([CH3:13])[CH2:11][NH2:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 962WaterHCID 214098442-Benzylmethylamino-2-methylpropionitrile

생성물 1

HCID 86733843HCID 86733843, 화합물수율 55.5%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of 2-benzylmethylamino-2-methylpropionitrile (6.7 g.) in ether (100 ml.) was added dropwise to a stirred solution of sodium dihydro bis[2-methoxyethoxy] aluminate (28.5 g.) in ether (150 ml.), kept at 0° C. The mixture was then gently refluxed for 20 hrs, and then excess reducing agent was decomposed by the dropwise addition of water to the cooled suspension. The mixture was dried (anhyd.Na2SO4), filtered (hyflo) and the excess ether evaporated under reduced pressure. The residual liquid was distilled under water pump vacuum to give 2-benzylmethylamino-2-methyl-propylamine (3.8 g.) b.p. 138°-140° C.

후처리

  1. customkept at 0° C
  2. temperatureThe mixture was then gently refluxed for 20 hrs
  3. dry with materialThe mixture was dried (anhyd.Na2SO4)
  4. filtrationfiltered (hyflo)
  5. customthe excess ether evaporated under reduced pressure
  6. distillationThe residual liquid was distilled under water

출처 및 근거

ORD 기록
ord-6d48ec0a115741d484345948ad46325e
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04049663

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