Thionyl Chloride → N-Cyano-N'-methyl-N"-[2-(2-(2-pyrimidyl)ethyl)thioethyl]guanidine

반응식

ClCCC1N=CC=CN=1.OCCC1N=CC=CN=1.S(Cl)(Cl)=O.[NH2:23][CH2:24][CH2:25][S:26][CH2:27][CH2:28][C:29]1[N:34]=[CH:33][CH:32]=[CH:31][N:30]=1.[C:35]([NH:37][C:38](=[N:41][CH3:42])SC)#[N:36]>>[C:35]([NH:37][C:38]([NH:41][CH3:42])=[N:23][CH2:24][CH2:25][S:26][CH2:27][CH2:28][C:29]1[N:30]=[CH:31][CH:32]=[CH:33][N:34]=1)#[N:36]

참가 물질

반응물 5

HCID 24386Thionyl Chloride

HCID 1111031-Cyano-2,3-dimethylisothiourea

HCID 205675002-(2-Chloroethyl)pyrimidine

HCID 205677192-[2-(2-Aminoethyl)thioethyl]pyrimidine

HCID 224935852-(Pyrimidin-2-yl)ethan-1-ol

생성물 1

HCID 178485017N-Cyano-N'-methyl-N"-[2-(2-(2-pyrimidyl)ethyl)thioethyl]guanidine

실험 절차

By the procedure of Example 17 using 2-(2-chloroethyl)pyrimidine, prepared by treating 2-(2-hydroxyethyl)-pyrimidine with thionyl chloride, as the starting material, 2-[2-(2-aminoethyl)thioethyl]pyrmidine is prepared, which when treated with N-cyano-N'.S-dimethylisothiourea by the procedure of Example 3(a) gives the title compound.