1-Isopropylpiperazine → 1-[2-Hydroxy-3-(4-isopropyl-1-piperazinyl)-4-oxo-2-cyclobuten-1-ylidene]-4-isopropyl-piperazinium hydroxide

HRID 2072286노트

반응식

HRID 2072286 반응식
[NH:1]([C:8]1[C:9](=[O:20])[C:10](=[N:13][C:14]2[CH:19]=CC=CC=2)[C:11]=1[OH:12])[C:2]1[CH:7]=CC=CC=1.[CH:21]([N:24]1[CH2:29][CH2:28]NCC1)([CH3:23])[CH3:22]>>[OH-:12].[OH:12][C:11]1[C:10](=[N+:13]2[CH2:14][CH2:19][N:24]([CH:21]([CH3:22])[CH3:23])[CH2:29][CH2:28]2)[C:9](=[O:20])[C:8]=1[N:1]1[CH2:2][CH2:7][N:1]([CH:8]([CH3:9])[CH3:11])[CH2:2][CH2:7]1

참가 물질

3

반응물 2

HCID 780131-IsopropylpiperazineHCID 109783293-Hydroxy-2-(phenylamino)-4-(phenylimino)-2-cyclobuten-1-one

생성물 1

HCID 214077881-[2-Hydroxy-3-(4-isopropyl-1-piperazinyl)-4-oxo-2-cyclobuten-1-ylidene]-4-isopropyl-piperazinium hydroxide

실험 절차

A mixture of 4.0 grams of 2-anilino-3-hydroxy-4-(phenylimino)-2-cyclobuten-1-one and 3.9 grams of 1-isopropylpiperazine is heated at 200°-206° C. in an atmosphere of dry nitrogen for 30 minutes. The mixture is cooled and the resulting solid is comminuted, washed with anhydrous ethyl ether, dried and then recrystallized from water to give 1-[2-hydroxy-3-(4-isopropyl-1-piperazinyl)-4-oxo-2-cyclobuten-1-ylidene]-4-isopropyl-piperazinium hydroxide inner salt melting at about 194.5°-196.5° C.

후처리

  1. temperatureis heated at 200°-206° C. in an atmosphere of dry nitrogen for 30 minutes
  2. temperatureThe mixture is cooled
  3. customthe resulting solid is comminuted
  4. washwashed with anhydrous ethyl ether
  5. customdried
  6. customrecrystallized from water

출처 및 근거

ORD 기록
ord-c6989ee03f27499196d869232cfe657b
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04051136

반응 노트

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