1,2,3,4-Tetrahydro-1-naphthylamine → 1-Benzoyl-3-(1,2,3,4-tetrahydro-1-naphthyl)urea

HRID 2072368노트

반응식

HRID 2072368 반응식
[CH:1]1([NH2:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[C:12]([N:20]=[C:21]=[O:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CCOCC>[C:12]([NH:20][C:21]([NH:11][CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1)=[O:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 180661,2,3,4-Tetrahydro-1-naphthylamineHCID 78210Benzoyl isocyanate

생성물 1

HCID 205373051-Benzoyl-3-(1,2,3,4-tetrahydro-1-naphthyl)urea수율 78.6%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A mixture of 1,2,3,4-tetrahydro-1-naphthylamine (10.01 g) and ether (100 ml) is stirred under a nitrogen atmosphere and a solution of benzoyl isocyanate (9.99 g) in ether (90 ml) is added dropwise. After the addition is completed, the mixture is stirred for 0.5 hour and cooled in ice. The product is collected and washed with cold ether (50 ml) to afford 15.7 g of the title compound, m.p. 166° to 169° C. Recrystallization from acetone affords 13.61 g, m.p. 171° to 173° C.

후처리

  1. additionAfter the addition
  2. stirringthe mixture is stirred for 0.5 hour
  3. temperaturecooled in ice
  4. customThe product is collected
  5. washwashed with cold ether (50 ml)

출처 및 근거

ORD 기록
ord-9056e843da3b40b6b9fc88851b80746c
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04051183

반응 노트

불러오는 중…