Diethyl Pyrocarbonate → 3-Amino-6-(trifluoromethyl)-1H-indazole

HRID 2072406

반응식

HRID 2072406 반응식
C(OC(OC(OCC)=O)=O)C.C(OC([N:17]1[C:25]([NH2:26])=[C:24]2[C:19]([CH:20]=[C:21]([C:27]([F:30])([F:29])[F:28])[CH:22]=[CH:23]2)=[N:18]1)=O)C>C(O)C>[NH2:26][C:25]1[C:24]2[C:19](=[CH:20][C:21]([C:27]([F:29])([F:28])[F:30])=[CH:22][CH:23]=2)[NH:18][N:17]=1

참가 물질

4

반응물 2

HCID 3051Diethyl PyrocarbonateHCID 537621583-Amino-6-trifluoromethylindazole-2-carboxylic acid ethyl ester

생성물 1

HCID 8179093-Amino-6-(trifluoromethyl)-1H-indazole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Analogously to Example 1, 0.04 mol of 3-amino-6-trifluoromethylindazole and 50 ml of pyrocarbonic acid diethyl ester in 25 ml of ethanol give 3-amino-6-trifluoromethylindazole-2-carboxylic acid ethyl ester (melting point: 153°-155° C; 77% of theory) in 1 hour at 20° C.

출처 및 근거

ORD 기록
ord-0f6a807b3d7a4481b86c1b96f9c9997a
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04051252

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