Diethyl Pyrocarbonate → 3-Amino-6-(trifluoromethyl)-1H-indazole

HRID 2072412

반응식

HRID 2072412 반응식
C(OC(OC(OCC)=O)=O)C.C(OC([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([C:26]([F:29])([F:28])[F:27])[CH:24]=2)[C:19]([NH2:30])=[N:18]1)=O)C>C(O)C>[NH2:30][C:19]1[C:20]2[C:25](=[CH:24][C:23]([C:26]([F:28])([F:27])[F:29])=[CH:22][CH:21]=2)[NH:17][N:18]=1

참가 물질

4

반응물 2

HCID 3051Diethyl PyrocarbonateHCID 536946653-Amino-6-trifluoromethylindazole-1-carboxylic acid ethyl ester

생성물 1

HCID 8179093-Amino-6-(trifluoromethyl)-1H-indazole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Analogously to Example 22, 0.04 mol of 3-amino-6-trifluoromethylindazole and 50 ml of pyrocarbonic acid diethyl ester in 25 ml of ethanol give 3-amino-6-trifluoromethylindazole-1-carboxylic acid ethyl ester (melting point: 168°-169° C; 64% of theory) in 2 hours at 80° C.

출처 및 근거

ORD 기록
ord-45663ffc510940dfb989d3afcbed9a56
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04051252

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