Aniline → 1-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotonitrile

HRID 2072477노트

반응식

HRID 2072477 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]=1[CH2:11][N:12]1[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]1.[NH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[C-:26]#[N:27].[K+].[OH-].[NH4+]>O.C(O)(=O)C>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]=1[CH2:11][N:12]1[CH2:17][CH2:16][C:15]([NH:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([C:26]#[N:27])[CH2:14][CH2:13]1

참가 물질

7

반응물 4

HCID 6115AnilineHCID 9032Potassium CyanideHCID 14923Ammonium HydroxideHCID 214082251-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-oxopiperidine

생성물 1

HCID 537070301-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotonitrile

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

반응 조건

온도
30 °C

실험 절차

A mixture of 1-[(3,4-dihydro-2-naphthalenyl)methyl]-4-oxopiperidine (24.0 g), aniline (9.3 g), and glacial acetic acid (70 ml) is cooled to 30° C and heated with a solution of potassium cyanide (7.2 g) in water (20 ml). The resulting mixture is stirred for 16 hours at room temperature. The reaction mixture is poured into aqueous ammonium hydroxide and extracted with chloroform. The organic solution is dried and concentrated to give the title compound.

후처리

  1. extractionextracted with chloroform
  2. customThe organic solution is dried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f55c85131ed143b1bd9418451088a7dd
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04051248

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