tert-Butyl (4-chlorobutyl)carbamate → Diethyl 2-(4-((tert-butoxycarbonyl)amino)butyl)malonate

HRID 2072820노트

반응식

HRID 2072820 반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12]Cl)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:14]([O:17][CH2:18][CH3:19])(=[O:16])[CH3:15].[OH2:20]>>[CH2:18]([O:17][C:14](=[O:16])[CH:15]([C:6]([O:5][CH2:1][CH3:2])=[O:20])[CH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH3:19]

참가 물질

3

반응물 2

HCID 19758183tert-Butyl (4-chlorobutyl)carbamateHCID 22728543Water ethylacetate

생성물 1

HCID 53641101Diethyl 2-(4-((tert-butoxycarbonyl)amino)butyl)malonate

실험 절차

N-[(tert-butoxy)carbonyl]-4-chloro-butylamine (2.5 g, 0.012 mol) is then gradually added to the resulting mixture at room temperature. The reaction mixture is stirred at room temperature for 2 hours and at the reflux temperature for 6 hours, and then poured into ethyl acetate/water (1/1, v/v) (100 ml). The organic phase is separated, washed several times with water, and dried over MgSO4.

후처리

  1. customThe organic phase is separated
  2. washwashed several times with water
  3. dry with materialdried over MgSO4

출처 및 근거

ORD 기록
ord-0b0cc111c0634abcb66deed5e4ca8dc8
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04914226

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