Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2072852생성일: 2026년 10월 25일
Diethyl Ether → 2,5-Methano-5H,9H-pyrimido(2,1-b)(1,5,3)dioxazepin-9-one, 2,3-dihydro-3-(hydroxymethyl)-8-methyl-, (2R,3R,5R)-
https://huagongshe.com/reaction/2072852
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Diphenyl carbonate | HCID 7597 | — |
| 반응물 | 5-Methyluridine | HCID 445408 | — |
| 촉매 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2,5-Methano-5H,9H-pyrimido(2,1-b)(1,5,3)dioxazepin-9-one, 2,3-dihydro-3-(hydroxymethyl)-8-methyl-, (2R,3R,5R)- | HCID 457982 | 101.4% |
반응 단계
A 100 mL round bottom flask equipped with magnetic stir bar, reflux condensor, and nitrogen inlet was charged with 5 g of ribothymidine, 4.7 g (1.2 eq) of diphenyl carbonate and 150 mg of sodium bicarbonate in 10 mL of DMF. The mixture was heated to 150° C. for 35 minutes. The black solution was diluted with 10 mL of MeOH and slowly added to 200 mL of diethyl ether. The tan product was filtered and dried to yield 4.4 g (96%) of anhydrothymidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04914233 |
|---|
| 출처 데이터셋 | uspto-grants-1990_04 |
|---|
| ORD ID | ord-c0b3691bde8f4128a9160c5ebc5206ac |
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| 출처 메모 | uspto-grants-1990_04 |
|---|
