Triethylamine → 2-(4-Chlorophenyl)-N-[4-(dimethylamino)phenyl]-N-methyl-3H-imidazo [4,5-b]pyridine-3-acetamide

A suspension of 2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridine-3-acetic acid (5.0 g, 0.0174 mole) in dry dimethylformamide (75 ml) was cooled in an ice bath and oxalyl chloride (2.2 g, 0.0172 mole) was added dropwise, with stirring, under nitrogen. The reaction mixture was stirred at room temperature for 3.5 hours and then N,N,N'-trimethyl-1,4-benzenediamine (2.9 g, 0.0193 mole) was added dropwise. The reaction mixture was stirred at room temperature under nitrogen overnight, poured into 400 ml of ice water and made basic with triethylamine (6 ml). The resulting white solid was collected by filtration, dissolved in hot isopropyl alcohol, treated with charcoal, and filtered while hot. Water was added to the cloud point and upon cooling, a solid precipitated. The gray solid was collected by filtration and rinsed with water to yield 6.6 g (92%) of product. A 1.0-g sample was dried under high vacuum to give 0.6 g of title compound, mp 152°-155° C.

1. temperaturewas cooled in an ice bath
2. stirringThe reaction mixture was stirred at room temperature for 3.5 hours
3. stirringThe reaction mixture was stirred at room temperature under nitrogen overnight
4. filtrationThe resulting white solid was collected by filtration
5. dissolutiondissolved in hot isopropyl alcohol
6. additiontreated with charcoal
7. filtrationfiltered while hot
8. additionWater was added to the cloud point
9. temperatureupon cooling
10. customa solid precipitated
11. filtrationThe gray solid was collected by filtration
12. washrinsed with water

ORD 기록

ord-3e04a6f683f64fb181b375430682c522

출처 데이터셋

uspto-grants-1990_04

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US04914109