Ammonium Hydroxide → 7-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

HRID 2073184

반응식

HRID 2073184 반응식
[C:1]1([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]#[N:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:18].[NH4+]>S(=O)(=O)(O)O>[C:1]1([C:7]2[N:12]3[N:13]=[CH:14][C:15]([C:16]([NH2:17])=[O:18])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 14804157-Phenylpyrazolo[1,5-a]pyrimidine-3-carbonitrile

생성물 1

HCID 145018607-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

A mixture of 4.0 g of 7-phenylpyrazolo[1,5-a]pyrimidine-3-carbonitrile (prepared as described in Example 7 of U.S. Pat. No. 4,236,005) and 40 ml of concentrated sulfuric acid was stirred at room temperature for 16 hours. The solution was then carefully poured into ice with stirring and the mixture was carefully made just basic with concentrated ammonium hydroxide. The solid was collected by filtration and recrystallized from dichloromethane to give pale yellow needles m.p. 236°-238.5° C.

후처리

  1. customprepared
  2. additionThe solution was then carefully poured into ice
  3. filtrationThe solid was collected by filtration
  4. customrecrystallized from dichloromethane

출처 및 근거

ORD 기록
ord-6ce34974c9db43c5961da614671bb131
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04916137

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