Sulfuric Acid → 4'-Chloro-2-hydroxymethylbenzhydrol

HRID 2073502

반응식

HRID 2073502 반응식
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10](O)=[O:11])=[O:7])=[CH:4][CH:3]=1.S(=O)(=O)(O)O>CO>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH:6]([C:8]2[C:9]([CH2:10][OH:11])=[CH:13][CH:14]=[CH:15][CH:16]=2)[OH:7])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 665642-(4'-Chlorobenzoyl)benzoic acid

생성물 1

HCID 197815594'-Chloro-2-hydroxymethylbenzhydrol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 55 g (0.3M) of 2-(4-chlorobenzoyl) benzoic acid, 5 ml of concentrated sulphuric acid and 500 ml of methanol was heated under reflux for 3 hours. The mixture was evaporated and the residue was taken up in dichloromethane washed with water then aqueous sodium bicarbonate. The dichloromethane was dried and evaporated. The residue was then reduced with lithium aluminium hydride in an analogous manner to that described in Example X1 to give the title compound.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. customThe mixture was evaporated
  4. washwashed with water
  5. dry with materialThe dichloromethane was dried
  6. customevaporated

출처 및 근거

ORD 기록
ord-c8d69d0943f44b218e9d062dc84daf2c
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04918083

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