HCID 85585332, 화합물 → HCID 11551221, 화합물

HRID 2073515노트

반응식

HRID 2073515 반응식
[N:1]([CH2:4][CH2:5][O:6][C:7]1[CH:20]=[CH:19][C:10]([CH2:11][CH:12]2[S:16][C:15](=[O:17])[NH:14][C:13]2=[O:18])=[CH:9][CH:8]=1)=[N+]=[N-]>CO.[Pd]>[NH2:1][CH2:4][CH2:5][O:6][C:7]1[CH:20]=[CH:19][C:10]([CH2:11][CH:12]2[S:16][C:15](=[O:17])[NH:14][C:13]2=[O:18])=[CH:9][CH:8]=1

참가 물질

4

반응물 1

HCID 85585332HCID 85585332, 화합물

생성물 1

HCID 11551221HCID 11551221, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 5-[4-(2-Azidoethoxy)Benzyl]2,4-Thiazolidinedione (5 g) in Methanol (100 ml) was reduced under hydrogen at ambient temperature and pressure in the presence of 10% palladium on charcoal (5 g) for 18 hours. The mixture was filtered through diatomaceous earth and the filter pad was washed exhaustively with Methanol. The combined filtrates was evaporated to dryness under reduced pressure and the title compound (m.p. 175°-6° C.) was obtained as a dihydrate following crystallisation from methanol.

후처리

  1. customwas reduced under hydrogen at ambient temperature
  2. filtrationThe mixture was filtered through diatomaceous earth
  3. washthe filter pad was washed exhaustively with Methanol
  4. customThe combined filtrates was evaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-f397d873a105467088b3b77f059efa28
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04918091

반응 노트

불러오는 중…