Water → Ethyl 2-(3-(2-(3-hydroxyphenyl)2-oxoethyl)phenoxy)acetate

HRID 2073905노트

반응식

HRID 2073905 반응식
[OH:1][C:2]1[CH:3]=[C:4]([C:8]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([OH:17])[CH:12]=2)=[O:9])[CH:5]=[CH:6][CH:7]=1.Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21].C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[OH:1][C:2]1[CH:3]=[C:4]([C:8](=[O:9])[CH2:10][C:11]2[CH:12]=[C:13]([CH:14]=[CH:15][CH:16]=2)[O:17][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 147741341,2-Bis(3-hydroxyphenyl)ethanone

생성물 1

HCID 14774136Ethyl 2-(3-(2-(3-hydroxyphenyl)2-oxoethyl)phenoxy)acetate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 3,3'-dihydroxydeoxybenzoin (0.05 mol), ethyl bromoacetate (0.05 mol) ad K2CO3 (0.05 mol) in 50 mL of DMF is stirred at room temperature overnight. The reaction mixture is poured into water and extracted with EtOAc. The organic solution is dried and evaporated to dryness. The crude products are separtated by flash chromatography to give the ethyl 2-(3-(2-(3-hydroxyphenyl)-2-oxoethyl)phenoxy)acetate and the ethyl 2-(3-(2-(3-hydroxyphenyl)-1-oxoethyl)phenoxy)acetate.

후처리

  1. extractionextracted with EtOAc
  2. customThe organic solution is dried
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-64e78115bf9d4228913b449b8c0205a9
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04920131

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