1-Acetyl-5-carbomethoxy-7-chloro-4-methoxy-1,2-dihydroindole → 1-Acetyl-5-carboxy-7-chloro-4-methoxy-1,2-dihydroindole

HRID 2074003노트

반응식

HRID 2074003 반응식
[C:1]([N:4]1[C:12]2[C:7](=[C:8]([O:18][CH3:19])[C:9]([C:14]([O:16]C)=[O:15])=[CH:10][C:11]=2[Cl:13])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>[OH-].[Na+].CO>[C:1]([N:4]1[C:12]2[C:7](=[C:8]([O:18][CH3:19])[C:9]([C:14]([OH:16])=[O:15])=[CH:10][C:11]=2[Cl:13])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

참가 물질

3

반응물 1

HCID 105649501-Acetyl-5-carbomethoxy-7-chloro-4-methoxy-1,2-dihydroindole

생성물 1

HCID 148832261-Acetyl-5-carboxy-7-chloro-4-methoxy-1,2-dihydroindole

시약·촉매·용매 1

HCID 23721981Sodium hydroxide methanol용매

실험 절차

A mixture of the indole ester of step 9 above (0.8 g) and 10% aqueous NaOH/MeOH (20 ml/80 ml) is stirred under reflux for 2 hours. The reaction mixture is concentrated and the aqueous residue is diluted with water and extracted with CHCl3. The organic layer is dried (MgSO4) and evaporated affording an off-white solid which is determined to be the desired compound by NMR.

후처리

  1. temperatureunder reflux for 2 hours
  2. concentrationThe reaction mixture is concentrated
  3. additionthe aqueous residue is diluted with water
  4. extractionextracted with CHCl3
  5. dry with materialThe organic layer is dried (MgSO4)
  6. customevaporated
  7. customaffording an off-white solid which

출처 및 근거

ORD 기록
ord-2d6adf4bd802410b97733c9b3797b538
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04920219

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