p-(Trifluoromethoxy)phenyl isocyanate → Ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylate

HRID 2074073노트

반응식

HRID 2074073 반응식
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]=[C:11]=[O:12])=[CH:6][CH:5]=1.[NH2:15][C:16]1[N:17]=[C:18]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:19]([CH3:21])[CH:20]=1>C1COCC1>[CH3:21][N:19]1[CH:20]=[C:16]([NH:15][C:11]([NH:10][C:7]2[CH:6]=[CH:5][C:4]([O:3][C:2]([F:13])([F:14])[F:1])=[CH:9][CH:8]=2)=[O:12])[N:17]=[C:18]1[C:22]([O:24][CH2:25][CH3:26])=[O:23]

참가 물질

4

반응물 2

HCID 92298p-(Trifluoromethoxy)phenyl isocyanateHCID 7006687ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate

생성물 1

HCID 59421902Ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Under argon, 1.46 g (7.21 mmol) of 4-(trifluoromethoxy)phenyl isocyanate are added to 1.22 g (3.61 mmol) of ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate (synthesis in analogy to Example 4A step 3, or also according to Tetrahedron Lett. 2003, 44, 1607 and the literature cited therein) in 50 ml of THF, and the mixture is stirred at room temperature overnight. The reaction mixture is filtered and the filtrate is concentrated in vacuo and purified chromatographically.

후처리

  1. customsynthesis in analogy to Example 4A step 3
  2. filtrationThe reaction mixture is filtered
  3. concentrationthe filtrate is concentrated in vacuo
  4. custompurified chromatographically

출처 및 근거

ORD 기록
ord-721dd9feeb6843cf82e5f636be6397c1
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07919489B2

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