Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 7-(4-bromobutoxy)-8-propyl-4-(trifluoromethyl)-2H-chromen-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 1,4-Dibromobutane | HCID 8056 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Trifluoromethyl-8-propyl-7-hydroxycoumarin | HCID 53701430 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 7-(4-bromobutoxy)-8-propyl-4-(trifluoromethyl)-2H-chromen-2-one | HCID 57963014 | 105.4% |
반응 단계
An N,N-dimethylformamide (5 mL) solution of 7-hydroxy-8-propyl-4-(trifluoromethyl)-2H-chromen-2-one (500 mg, 1.84 mmol), 1,4-dibromobutane (2.19 mL, 18.36 mmol), and potassium carbonate (375 mg, 2.76 mmol) was stirred overnight at room temperature. The reaction solution was added with water and extracted with ethyl acetate. Subsequently, the organic layer was washed with saturated saline, dried using anhydrous sodium sulfate, and concentrated under vacuum. The obtained residue was purified using silica-gel chromatography (hexane:ethyl acetate=10:1), and the title compound (0.79 g) was obtained as yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07919509B2 |
| 출처 데이터셋 | uspto-grants-2011_04 |
| ORD ID | ord-57a940b758594132aef2836b23d3e696 |
| 출처 메모 | uspto-grants-2011_04 |