Toluene → N-(3,5-bis(trifluoromethyl)benzylidene)(2-chloro-5-(trifluoromethyl)phenyl)methanamine

HRID 2075116

반응식

HRID 2075116 반응식
C1(C)C=CC=CC=1.[Cl:8][C:9]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][C:10]=1[CH2:11][NH2:12].[F:21][C:22]([F:36])([F:35])[C:23]1[CH:24]=[C:25]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[CH:26]=O.C1(C)C=CC(S(N)(=O)=O)=CC=1>O>[F:21][C:22]([F:35])([F:36])[C:23]1[CH:24]=[C:25]([CH:28]=[C:29]([C:31]([F:34])([F:32])[F:33])[CH:30]=1)[CH:26]=[N:12][CH2:11][C:10]1[CH:13]=[C:14]([C:17]([F:18])([F:19])[F:20])[CH:15]=[CH:16][C:9]=1[Cl:8]

참가 물질

6

반응물 4

HCID 1140TolueneHCID 6269P-ToluenesulfonamideHCID 1362473,5-Bis(trifluoromethyl)benzaldehydeHCID 27366822-Chloro-5-(trifluoromethyl)benzylamine

생성물 1

HCID 86614963N-(3,5-bis(trifluoromethyl)benzylidene)(2-chloro-5-(trifluoromethyl)phenyl)methanamine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a 100 mL round bottom flask, equipped with a Dean Start Trap was charged 50 mL of toluene, 5.0 gm of 2-chloro-5-trifluoromethyl benzyl amine and 5.8 gm of 3,5-bis(trifluoromethyl)benzaldehyde and 50 mg of para-toluenesulfonamide. The reaction was heated until water no longer distilled off about 3 hours, then cooled to ambient temperature and the solvent removed in vacuum. The crude product was used directly in the next step without further purification. 10.0 gm.

후처리

  1. customTo a 100 mL round bottom flask, equipped with a Dean Start Trap
  2. distillationno longer distilled off about 3 hours
  3. customthe solvent removed in vacuum
  4. customThe crude product was used directly in the next step without further purification

출처 및 근거

ORD 기록
ord-e74a2df1db8f40e3a4998c9d58add5de
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07919506B2

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