Trifluoroacetic acid → HCID 178522030, 화합물

HRID 2075770노트

반응식

HRID 2075770 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:33])=[C:6]([C:8]2[C:12]([C:13]#[C:14][C:15]3[CH:20]=[CH:19][C:18]([NH:21][C:22]([C@H:24]4[CH2:29][CH2:28][CH2:27][CH2:26][NH:25]4)=[O:23])=[CH:17][CH:16]=3)=[CH:11][N:10](CCO)[N:9]=2)[CH:7]=1.C(OC(N1CCCC[C@H]1C(=O)NC1C=CC(C#CC2C(C3C=C(Cl)C=CC=3O)=NNC=2)=CC=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:33])=[C:6]([C:8]2[C:12]([C:13]#[C:14][C:15]3[CH:16]=[CH:17][C:18]([NH:21][C:22]([C@@H:24]4[CH2:29][CH2:28][CH2:27][CH2:26][NH:25]4)=[O:23])=[CH:19][CH:20]=3)=[CH:11][NH:10][N:9]=2)[CH:7]=1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 135974922HCID 135974922, 화합물HCID 178451867HCID 178451867, 화합물

생성물 1

HCID 178522030HCID 178522030, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Using the same procedure for the preparation of compound 5A, treatment of compound 25A with TFA in methylene chloride gives the title compound 26A as a white powder in similar yield. LCMS (ESI) m/z 421.03 (MH+, 100); HPLC: tR=4.08 min.

출처 및 근거

ORD 기록
ord-b7ca30b006a44d37809e1653c7019208
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07923004B2

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