Ammonia → HCID 178492429, 화합물

HRID 2075946노트

반응식

HRID 2075946 반응식
[CH2:1]([O:8][C:9]1[C:18]([O:19][CH3:20])=[CH:17][C:12]([C:13](Cl)=[N:14][OH:15])=[C:11]([I:21])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[N:23](C)C=O.N.C(OCC)(=O)C>O>[CH2:1]([O:8][C:9]1[C:18]([O:19][CH3:20])=[CH:17][C:12]([C:13]([NH:14][OH:15])=[NH:23])=[C:11]([I:21])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 222AmmoniaHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 866472264-benzyloxy-N-hydroxy-2-iodo-5-methoxy-benzimidoylchloride

생성물 1

HCID 178492429HCID 178492429, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To a mixture of 4-benzyloxy-N-hydroxy-2-iodo-5-methoxy-benzimidoylchloride and N,N-dimethylformamide (110 mL) was added a 28% ammonia in water (12 mL) under ice-bath cooling. After stirring for 3 hours under ice-bath cooling, water and ethyl acetate were added to the mixture. The separated organic layer was washed with water and brine successively, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was triturated with hexane:diethyl ether=1:4 to give the title compound (9.3 g).

후처리

  1. temperaturecooling
  2. temperaturecooling
  3. washThe separated organic layer was washed with water and brine successively
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was triturated with hexane

출처 및 근거

ORD 기록
ord-0aa487be90be4afebf7bf65fe3b0e39d
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07923462B2

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